Pitch VC23

108Labs is the pioneer of cell-cultured human milk and human milk immunoglobulins, and developing cell-cultured milk and immunoglobulins products with a factory-scale platform called M2 to enable global scaling of cell- based milk production for diverse fields such as infant formula and other breast milk substitutes, bovine cheeses, butters, yogurts, ice creams and any milk-derived product derived from animals today.

Achelios is a clinical-stage company with a proprietary topical formulation platform, currently developing three drug candidates for chronic pain and opioid avoidance, Menstrual Migraine, and Temporomandibular joint pain.

Active Defender builds and delivers game changing emergency communications. Picture this: You’re standing in the cafeteria and hear an alarm. You know there is a threat, but you don’t know what it is or where it is. As you navigate toward an exit, you have no way of knowing if you’re moving away from danger or right in its path. Now, imagine if you had all of those answers in seconds with personalized guidance getting you to safety. Active Defender can give everyone those answers, empowering them to make the right decisions at the right time.

Acuity Health was founded by a consortium of the nation’s leading behavioral health organizations to leverage the experience of 40 health systems sharing inpatient data for over a decade. Beginning in 2011, these health systems formed the Harbor Performance Initiative (HPI), a collaborative effort to improve the quality of inpatient psychiatric care and to enhance operational best practices in a changing behavioral healthcare and reimbursement environment. The aggregate results were extremely positive and estimated in one year alone that over 200,000 fewer Americans experienced seclusion or restraint in their psychiatric hospitals.

Ad Astra Diagnostics (AAD) enables fast, point-of-care health decisions with the QScout line of easy-to-use POC diagnostics. Ad Astra’s QScout RLD is the world’s fastest imaging-based dry hematology analyzer providing the main components of a CBC (including a 6-part differential) in 2 minutes. It is the only system to quantitate immature infection-fighting cells that are markers of sepsis in a system that can be used POC or mobile. The company has commercial experience developing, manufacturing and supporting similar equipment through sister company Advanced Animal Diagnostics, which markets rugged, point-of-cow diagnostics for early disease detection and precise targeting of antibiotics.

Aerami is a clinical stage biopharmaceutical company dedicated to breathing life into the treatment of serious cardiopulmonary conditions, such as pulmonary hypertension. Our lead asset, AER-901 (inhaled imatinib), is poised to enter Phase 2 in pulmonary arterial hypertension (PAH) in mid 2023.

Creating the next generation of synthetic fibers and polymers from plants for consumer goods and fashion & apparel.

All Elements is reinventing people management for workplaces in traditional industries.

Allergood is a B2B company transforming what it means to dine out by creating interactive menus that automatically filter for the top 10 allergens as well as dietary preferences like vegan, vegetarian, pescatarian, Keto, and Paleo, dietary needs that affect 42% of Americans. In turn, we help our target customers, national restaurant and resort chains, boost revenue and increase customer loyalty, while providing key insights for use in menu design, menu optimization and product development.

Altopa has developed Oblend, a platform that provides the blueprint for care providers to treat patients with natural botanical medicine. Oblend is the 1st countertop machine that creates personalized plant-based formulations with pharma-grade precision on demand. Oblend’s platform collects real world data and enables care providers to recommend proven plant-based formulations and, based on patient feedback, customize the ingredients to address each individual’s unique needs.

Amalgent Therapeutics, Inc. is a clinical-stage startup developing novel pain treatment solutions that directly address the underlying causes of the ongoing global opioid crisis. Founded in 2020 by Malcolm Meyn and Sam Tetlow, Amalgent has an exclusive license to an opioid adjuvant technology invented at East Carolina University. Animal and human studies show this technology works to decrease the doses of opioids needed to treat pain while simultaneously decreasing their addictive properties. We are developing this adjuvant technology as part of a highly innovative combination therapeutic. Bringing this new therapeutic to the market will decrease opioid use and minimize the chance that acute, chronic, and cancer pain patients will have opioid side effects, including addiction.

Aniluxx Biotechnology is on a mission to improve companion animal health and well-being. The Company’s strategy is to translate its deep pipeline of topically formulated therapeutics, predicated on compounds that have already been identified as safe and effective in humans, into therapies for dogs, cats, and horses, that are easy to apply, virtually unnoticeable, and treat the symptoms of disease quickly.

Archaius focuses on GPS-denied navigation, protecting GPS reception against jamming and spoofing while also developing a disruptively precise navigation sensor for times and places where GPS is unavailable.

College certificates, professional certifications, and licenses; nearly 1 in 3 working-age adults has earned a professional credential. These credentialing documents make up our professional identities. We rely on them when competing for jobs. Yet, the nearly 50 million credentialed workers in the US have no consistent way to store or share their credentials. This critical information is easily lost between institutions and employers. With today’s workforce shortages, neither employees nor employers can afford credentialing delays. ArchiveCore works alongside an organization’s current process to provide secure credential storage, sharing, and verification to minimize credentialing delays.

Disaster recovery and ransomware protection for cloud workloads.

Avalo accelerates the creation of new crop varieties using machine learning, which reduces development time and cost by three times and quickens the transition to a more sustainable, climate-resilient food system.

Avior Bio is a clinical-stage, pharmaceutical company advancing therapies for the treatment of pruritus (itch) and inflammatory skin disease in chronic liver disease, especially Primary Biliary Cholangitis. Our lead product – AV104 buccal film – is the first-in-kind, dual-action, liver-safe product. We are seeking $6 million in investment for a well-defined, straightforward clinical phase II study to be completed by 2024. We are also actively seeking a pharmaceutical partner interested is addressing this critical unmet need in 2.5 million liver patients. AV104 is protected by two issued patents (until 2041) and six pending US patent applications. We completed all IND enabling nonclinical toxicology and successfully completed three Phase I studies and have excellent results to share on our product performance.

AyuVis designs, synthesizes, and develops novel, small molecule immunotherapies to prevent and treat inflammatory and infectious diseases by modulating the innate immune system. The lead drug candidate is at the IND-stage and has been granted Orphan Drug and Rare Pediatric Disease Designations by the FDA for the lead indication, the prevention of bronchopulmonary dysplasia (BPD) in preterm infants. Follow-on high unmet need respiratory applications of the lead drug candidate include acute respiratory distress syndrome (ARDS), Multi-Drug Resistant (MDR) ventilator-associated bacterial/viral pneumonia, and ventilator- associated lung injury. Our lead series of drug candidates are based on a platform technology of macrophage modulation.

Baiya Phytopharm is an Asia based biotech company established by a global leader in plant-based molecular farming and an experienced health economist with over 10 years of front-line experience in medicine access strategies for pharma. Baiya Phytopharm’s plant-based technology, “Baiyapharming”, is a cutting-edge solution aiming to replace conventional bioreactor with plants. The platform has the flexibility to produce recombinant proteins that could be used as therapeutic proteins and vaccines.

BatteryXchange provides reliable access to portable energy for all, while providing a tool for companies to engage with their target audience within their own spaces. We’ve built innovative charging stations that provide free portable batteries through an immersive mobile app experience. Within the app, customizable ad placement allows enterprise businesses to share content and important information while also receiving insights & learning from the captive audience. And lastly, we’ve built an API that allows businesses with native mobile apps to integrate the BatteryXchange experience into their own ecosystems.

With technology licensed from North Carolina State University, Bay Nano is disrupting advanced nano materials industries by using artificial intelligence (AI), machine learning (ML) and autonomous & continuous manufacturing to bring advanced nanomaterials to market in timeframe of months instead of years/decades and at 1/6 the cost of the competition. Quantum dots (QD) for displays and electrochromic smart windows are our beachhead products. We will achieve revenue in 6-9 months with QDs for displays. We are in the product verification and lifecycle testing with a major customer and negotiating a $10M+ order.

We are a digital health company making it easier for doctors and patients to address behavioral health risks. We are raising a $2M seed round to develop our marketing and sales infrastructure. BEAM is eliminating stigmatizing and confusing paper/pencil behavioral assessments by building digital solutions based on the novel science of behavioral economics. Our platform offers the ability to assess patient risks in shorter times, without stigmatizing or difficult questions. This lowers the barriers to care for patients while empowering doctors to provide proactive care. Our team has experts with more than 75 total years of behavioral economics research experience combined with technology and clinical expertise.

Beam is an enterprise asset management solution for the broadcast, film and Pro- AV industry that links assets to product-level data & insights from hundreds of sources. Beam’s Asset Intelligence PlatformTM allows engineers to perform work faster and more efficiently with dynamic data & notifications from thousands of vendors, manufacturers and production engineers in one simple interface.

BioAesthetics Corporation is a biotechnology company focused on transforming lives through advancements in biomaterials. Its inaugural product is a tissue- engineered nipple-areolar complex graft (NACgraftTM Acellular Allograft) for patients who are undergoing breast reconstruction generally following breast cancer and mastectomy. NACgraft has been registered the FDA as an HCT/P, and is currently in two clinical studies. In addition, it has a product pipeline focused on acellular regenerative grafts for advanced wound and reconstructive care. BioAesthetics was founded as a spin-out of Tulane University in New Orleans, LA and is now located in Durham, NC.

BlueRecruit is a direct-hire marketplace for skilled-trade workers who want to build their careers and the companies desperate their talent. BlueRecruit removes the inefficiencies of resumes and job posts and focuses of the skills and experiences that matter in the trades.

BNNano is an advanced manufacturing company located in Burlington, NC, that pioneered the patent pending NanoBarbTM, a unique and enhanced Boron Nitride Nanotube. When NanoBarbsTM are added to other materials, they improve their natural properties making them extraordinary. But what does that mean? It means that aluminum may become as strong as steel or titanium, that copper can provide advanced thermal management solutions, and heat sinks can be made from plastics, that standard filtration media can remove PFOA’s from water, that polyester can behave like Kevlar and our materials can provide new capabilities in water purification, fire prevention and enable hypersonic travel just to name a few.

There are over 500,000 liquid nitrogen tanks in use around the world to store irreplaceable biological materials such as embryos and stem cells. Current methods for monitoring these tanks are inadequate in preventing failure events that result in the loss of stored biological materials. These losses are not only emotionally devastating for the individuals involved they are also financially disastrous for the clinics responsible for safeguarding these irreplaceable assets. Boreas was born out of a need for a solution that will prevent these types of failures from ever occurring, and we are doing this by providing the safest, most reliable tank monitoring system ever made. Boreas Monitoring is a technology company that has developed a patented system to monitor liquid nitrogen tanks in the fertility industry.

Boulo is a success platform for working mothers. We know mothers are leaving the workforce at the highest rate in history because of lack of flexibility, lack of career progression and lack of professional support. We tackle these three challenges by matching our >12,000 members with flexible jobs, offering our progressive learning platform and curating a marketplace of supportive solutions. Employers have a new pipeline problem – women. We work with employers willing to offer flexible roles to find highly skilled talent not often found on other platforms.

Bristles leverages AI and computer vision integrated into an easy-to-use mobile app to help the everyday consumer plan and design home improvement projects from painting outdated furniture to refreshing a bathroom or kitchen. Our proprietary technology enables users to visualize paint colors realistically, applied to any surface, erase hardware and fixtures while preserving structural lines, and add new materials and products. And our users can do it all using only images of paint colors and products, eliminating the complexity and expense of 3D models traditionally required for home design software.

An alternative digital financing platform that unlocks working capital and provides minority SMEs access to cash quickly.

CareNexis is a Consumer Health SaaS platform that helps consumer health brands identify and understand target audiences, and provides the tools to improve performance across search, discovery, and eCommerce conversions.

CareWork is the first-ever holistic software platform for long-term care providers and senior living organizations that unifies and streamlines operations. Through integration, business intelligence, workflow, and automation, CareWork helps care providers identify problems before they occur and gives their teams the tools to work faster, more efficiently, and with greater operational insight.

Over 53 million Americans are caring for an elderly parent, a seriously ill spouse, or a child with special needs. CareYaya’s tech platform lets you book great caregivers for family, quickly online, at half the price of traditional options. Our mission is to enable family caregivers to return to the workforce.

Cellular Farms is a innovative vertical farming company focused on growing nutrients and not salads. We are focused on providing lab quality nutrients, compounds and enzymes to the pharmaceutical, nutraceutical and supplement markets. We have both a B to B platform as well as a B to C brand and distribution channel.

Chekhub is a B2B SaaS software company founded in March of 2020 by serial entrepreneur Jon Trout. The company’s vision is to create a software solution to solve the operational challenges he faced in his last startup, Bitbox USA. Chekhub’s focus is to provide an operational management software platform to help provide clarity, precision, and efficiency to your entire organization. Chekhub’s focus is to help operational leaders improve their organizations performance similar to how Salesforce helped sales leaders.

CINCH Community Care Management is the home care industry’s first cloud-based mobile technology that addresses the gaps that exist incurrent software systems. It provides caregiver assignments and real-time tools to help agencies easily and efficiently manage community care services in independent living communities. It was designed by homecare agency owners for home care agency owners. It is a proven system, patent pending (#507289800) and is already helping our seniors here in RTP.

Clever Education Solutions (CES) engages in the development and commercialization of a cloud-based, end-to-end school management software (SaaS). Its target market is the Montessori and independent schools in North America and abroad. CES’ mission is to eliminate the schools’ administrative burden in order to concentrate on providing great education to their students and building vibrant and inclusive communities.

Coprata is a health tech company that captures data from human waste to improve health and wellness via smart toilets.

Couplet Care, LLC offers tools for improving patient safety and clinical efficiency, while promoting positive mother and infant health outcomes. Our first product, a postnatal unit medical infant bassinet, is a University of North Carolina spin-out, 510(k) Exempt, Class II Medical Device, with a US Patent, exclusive IP, strong interest from hospitals, and is in 4th generation prototype. The Couplet Care Bassinet is designed to reduce the risk of infant drops, infant suffocations and maternal pain while improving clinical efficiency and facilitating breast-feeding. The SBIR Phase I usability pilot study showed a 73% reduction in mom calls to the nurse and a 60% reduction in infant time out of the room, translating into approximately $250,000/year for a 20 bed unit in nurse time being used for non- medical reasons.

Coworks is a coworking and flexible workspace management platform. Our mission is to be the operating system for the modern flexible workspace. Our platform is a full service operations system that manages scheduling, payments, room/desk reservation, and lead and member management. We sell directly to space operators and empower them to create operational efficiency while accessing key spatial data. Our member app allows the members in each space to easily access space resources, events, and community. Together we are able to provide key data and metrics to space managers around usage, growth, and community engagement while allowing the people in the space to easily understand how to utilize and access the workspaces on demand.

CytexOrtho is a healthcare startup that is developing technology and solutions for younger patients with hip pain to address early joint degeneration. The company’s lead product is a cutting-edge biodegradable medical implant that restores joint cartilage and bone instead of replacing it with artificial materials found in a total joint replacement. While this product is not yet commercially available, CytexOrtho is currently preparing for an FDA IDE submission to begin clinical trials for it and expects to begin these trials in 2023.

CytoRecovery is a Delaware C Corporation founded in 2017 to advance and commercialize new technology developed in the Laboratory of Dr. Rafael Davalos, Professor of Bioengineering at Virginia Tech, that revolutionizes the ability to sort and recover live cells from tissue and other biological samples. Frustrated by the inability of current methods to recover a rare type of cancer cell (known as Cancer Stem Cells believed to be able to cause tumor regeneration), Dr. Davalos and his team created new technology that rapidly separates and recovers live cells. The Davalos laboratory proceeded to publish the successful recovery of cancer stem cells, using their laboratory’s proprietary technology platform. The Davalos/Virginia Tech technology has been exclusively licensed to CytoRecovery.

Deep Blue has developed the novel T-Line® Hernia Mesh to address the unacceptably high rate of hernia occurrence and recurrence. Millions of hernia surgeries are done globally with billions of dollars in clinical cost. Our surgeon- invented mesh design with integrated suture-like extensions eliminates the key point of failure for conventional mesh fixation and provides superior anchor strength. The portfolio of Deep Blue products available and in development enhance hernia surgery with a significant impact on the multi-billion dollar global hernia device market. Due to its simple design, the T-Line Hernia Mesh will reduce hernia recurrence by preventing mesh fixation failure. Deep Blue has a full portfolio of hernia products in development to meet the needs of every patient group and surgeon preference.

Doctors are overwhelmed, and their patients are missing out on life-saving preventive care. This damages healthcare systems’ quality ratings and bottom line. DHN Solutions addresses this critical problem with mPATHTM, an automated direct-to-consumer program that finds individuals who need a preventive care service, provides personalized education, and empowers patients to “self-order” needed care. mPATHTM is founded on over 10 years of research and more than $6 million in competitive funding from the NIH.

Dignify Therapeutics is focused on developing novel bowel and bladder therapies to restore voluntary control of voiding and eliminate or reduce incontinence episodes, manual bowel programs, and bladder catheter use. The inability to efficiently empty the bowel and/or bladder is a common problem in individuals with spinal cord injury (SCI), diabetes, multiple sclerosis (MS), stroke, Parkinson’s disease (PD), spina bifida, post-operative urinary retention (POUR) and the elderly. There are no safe, efficacious, and convenient drug therapies available for inducing on-demand defecation or urination. Current management programs include manual bowel programs, enemas, laxatives, bladder catheterization, and diapers, which are cumbersome, stigmatizing, and often lead to secondary complications and infections.

Dime is the end-to-end, technology-driven platform to empower Gen Z businesses.

DNALI is a biotech startup company that is focused on revolutionizing the DNA synthesis industry by providing high-yield, chemically-modified DNA sequences. Our technology solves the problem of synthesizing modified oligos at high cost by using a novel continuous enzymatic process that operates in gentle biological buffers. This technology is disruptive as it opens up new possibilities in the Bioeconomy, including applications in biomedical research, pharmaceuticals, industrial biotechnology, and clinical and environmental diagnostics.

A Discover Global Network partner providing a fintech solution to empower guilt- free gaming! We enable users to utilize spare change round-ups and bank deposits to auto-fund their sports bets without breaking the bank.

DragonFly provides a Sports Managment Platform targeted at Education based athletic programs. We solve the problem of connecting Governing Bodies such as the NCHSAA with member schools, coaches, parents, Contest Officials, and Athletes. We provide documentation, eligibility, and financial management to the Athletic Silo of High Schools by giving Athletic Directors and Finance Officers a singular view of the department. This also allows us access to over 2500 high schools, 500000 student athletes, and the passionate fan base this represents. Our partners include the national High school governing body NFHS, the NCHSAA, AHSAA, MHSAA, NMAA, to name a few

Drive Therapeutics is a privately-held, seed-stage company that is actively raising funding to advance the development of its lead program, which is a bispecific aptamer therapeutic made up of two well validated components: a pan-specific anti-VEGF-A aptamer and an anti-Interleukin-8 (IL8) aptamer. Drive’s management team is led by Doug Gooding (CEO), who brings over 25 years of experience in working with, and managing, early-stage venture backed companies with a particular focus on early-stage drug discovery and development.

E-Sentience is building a technology platform that uses wearable devices to help people better understand and moderate their physiological and psychological health in real time. We are starting by building the first commercially-available device that measures stress directly through “the stress hormone” – cortisol. Cortisol is a component of sweat, and, as humans are constantly sweating at a low baseline level, we can collect continuous, non-invasive biometric data from our discrete and comfortable arm sleeve. The device will also measure heart rate, skin conductance, blood oxygenation, and skin temperature.

EasyVote Solutions provides software-as-a-service (SaaS) applications that streamline the processes behind running successful elections. Our customers are city, county and state elections offices across the United States, who find that the EasyVote Election Management Platform: Reduces the time it takes to perform election tasks. Improves communication and accuracy between officials and election workers. Provides data, enabling election officials to make intelligent, informed decisions.

Ecobot is a cloud-based platform that supports efficiency throughout the construction lifecycle by optimizing data collection and management for environmental permits and enables customers to utilize data in a variety of contexts. Ecobot helps customers deliver data consistency across a distributed workforce and enables them to leverage field data for operational, cost, and climate-change-resilient improvements to the construction lifecycle.

Edison Marks is an automated risk ratings platform solving the gap between the ever-growing threat of cyber attacks on small and medium enterprises and the poor fit solutions offered by enterprise solution providers.

Eldec Pharmaceuticals is a pre-clinical stage platform company, that is developing novel, peptide-based therapeutics to treat inflammation, bacterial and viral infections. Eldec is based in Durham, NC and has received over $5M in NIH grant funding. Eldec is currently looking for investment to advance the lead asset, ELD607 into clinical trials.

ELDR is an all-in-one platform/marketplace mobilizing the growing end of life planning profession to simplify, organize, and lead an overdue culture change.

EnFuego Therapeutics is a pre-clinical stage biotechnology company developing RNA-based therapeutics to target difficult-to-target cancer genes.

Technology solutions company. We look for problems to solve in animal production mainly swine and poultry by using existing technology that is stitched together in a unique way.

Multiple rare diseases and cancers driven by single gene mis-regulation (i.e., a gene that is inappropriately turned on or off). Epigenos Biosciences is developing a two-component tunable therapy which combines site-specific DNA binding technologies with a novel small molecule that links the DNA binding module to host chromatin modifying enzymes in a dose-dependent manner. In the long-term, the modular nature of Epigenos’ platform will provide a precise epigenetic therapy that can be refined in real time to meet the therapeutic needs of the patient.

Equity Shift helps private companies of all types accelerate the execution of their business strategy. Our patented platform combines valuable functionality for operators with rules-based workflow automation that streamlines legal processing and creates outcomes that are transparent, compliant, and easily repeatable. Equity Shift is approachable and scalable for organizations of any type, size, and growth stage.

Essential Personnel is a B2G SaaS workforce management and safety/wellness solution built for public safety agencies. The software enables leaders to track and identify personnel data that is most critical to maintaining accountability, high- morale, and the readiness of their organization. For Chiefs, Sheriffs and municipal government leaders seeking to modernize their performance development and talent management methods, Essential Personnel (EP) provides one repository for all their agency’s “People data”. Building a strong team requires physically and mentally ready personnel. EP provides safety/wellness leaders and peer support programs with robust data and reporting tools for injuries, exposures, and critical incidents.

F3TCH is a patented mobile application for hotels & resorts. F3TCH converts the guest’s own smart device (phone or tablet) into the hotel telephone during the guest’s stay. F3TCH helps hotels & resorts maximize the non-lodging revenue (e.g., Room Service) which is almost 40% of the industry’s total revenue in the US and is a market worth $95 bn per year. F3TCH offers Voice, SMS, and Rich Text to its hotel clients enabling them to communicate more meaningfully with their guests while simultaneously helping them upsell their services & amenities, increase their efficiency, and improve guest satisfaction.

Fathom Science delivers The Ocean, At Your Fingertips. By creating high- resolution, high-fidelity Ocean Intelligence with data analytics and forecasting, we support operations and decision making for a wide variety of industries in the Blue Economy. Our technology applies state-of-the-art marine environment modeling and observational data assimilation, enhanced by AI and machine learning techniques. In addition to forecasts, hindcasts, and near-real-time conditions, Fathom’s data analytical models can provide digital twins of the coastal and marine environment, which empower users to explore risks associated with different scenarios and better understand potential impacts of their planning decisions.

Floodlight Software provides a SaaS platform for digitalizing and managing end- to-end testing and inspection operations. Nondestructive testing (NDT) and other regulated testing processes can be fully managed within Floodlight, which keeps an auditable and structured digital record of all activity associated with an inspection process.

Free to Feed helps parents navigate food allergies through science-based products, services, and content. We are building an over-the-counter allergen test that identifies various food proteins in breast milk. The users are both breastfeeding parents who suspect infant food allergy/intolerance as well as breastfeeding mothers who wish to deliberately introduce food allergens to their infant early and often as recommended by the AAP. These parents understand and appreciate the benefits of nursing as the healthiest, natural form of infant nutrition.

FreeFlow Medical Devices (FreeFlow) is a start up with a mission to improve outcomes for patients with implantable medical devices through the use our revolutionary TLP coating technology licensed from Harvard’s Wyss Institute. This novel coating (tethered liquid perfluorocarbon or TLP) can be applied to catheters to prevent the major causes of catheter and thus treatment failure, which costs the US healthcare system over $20B in annual costs. Our first products will be hydrocephalus catheter shunts, external ventricular drains (EVDs), and hemodialysis catheters. Two different large animal model studies have been completed, demonstrating significant reduction in the mechanisms that cause current catheter clogging.

Glamo is a beauty on demand marketplace that connect clients with their own personal stylist in the comfort of their home within minutes of booking.

Glycan Therapeutics offers innovative solutions for design, synthesis, analysis, and validation of glycosaminoglycans (GAGs) specifically heparan sulfate (HS) and chondroitin sulfate (CS). Glycan Therapeutics activities include producing and selling research reagents, analytical and microarray services, and a drug development program. Research reagents division is focused on specialized tools for glycobiology research. These products include heparin, HS and CS oligosaccharide standards. The reagents are essential for HS and CS-based drug discovery that is driven by the role of HS and CS in regulating inflammation, suppressing cancer growth, and blocking viral infections. Glycan Therapeutics’ products are now sold worldwide with an increasing visibility of the company among scientific communities.

GoalMakers provides a 10-week ‘mini-MBA’ program to make business education accessible, effective, and enlightening. Our business model is to partner with trade associations and white-label our program with their branding to create an ‘in- house’ education offering covering this crucial topic. This B2B2C model allows us to have a highly engaged customer base without spending a single cent on marketing. Our team creates a turnkey delivery system for the association’s marketing team to promote this new program to their members. All of this, is at no cost to our association partners, in fact, they actually receive a revenue share of the shared success. In turn, providing a valuable new member benefit and a scalable non-dues revenue source for the association.

Gradient Medical is a medical device startup company developing next generation technologies for the treatment of cancer using pulsed electric fields. The companies patented INSPIRE technology has been used in over 100 clinical cases at the NCSU college of veterinary medicine. With three SBIRs and NIH Academic- Industrial Partnership funding, the company is currently finalizing clinical instrumentation and disposables and conducing safety/reproducibility studies.

Green Solutions Group, LLC (GSG) is a North Carolina company that created nontoxic tissue preservatives for use in mortuary science, all subsets of pathology, surgical training, and medical education. GSG’s products are trademarked, patented, and certified as nontoxic by independent third parties. These nontoxic products will raise the educational and safety standards for surgical and medical training, which will enhance the practice of medicine worldwide. It is our mission to become the gold standard in tissue preservation. Toxic chemicals, such as formaldehyde, glutaraldehyde, phenol, ethylene glycol, and methanol have been the only options for tissue preservation for decades. To our knowledge, GSG is the first and only company in the world to offer nontoxic products for tissue preservation.

HANK is a targeted AI platform for curing healthcare’s high cost, low quality problem. Current focus is disrupting healthcare revenue cycle – the core driver of all decisions in healthcare and the source of the data honeypot needed to build disruptive healthcare AI.

GroupUps is a marketplace platform for SMBs to group purchase large capital equipment from vendors and distributors.

Happyly is the employee connection and wellness platform supporting the intersection of work and life. Happyly empowers companies to create a connected culture resulting in greater productivity, morale, and retention. The platform enables companies to drive culture, wellness, and corporate social responsibility initiatives across distributed teams.

Helixomer is a biopharmaceutical development startup out of NC State University with a proprietary RNA-origami-based platform technology. Our first products are an intravenous anticoagulant and its reversal agent that have demonstrated safety and efficacy in animal models and in human plasma. We have secured an exclusive license agreement with NCSU for the critical IP (US Provisional Appl. 62/750,900), (PCT/US19/58133), (related National patents – US, EU, Canada, Australia, China, Japan), and (U.S. Provisional Application, 63/230,153). This IP is based on work in LaBean’s lab at NCSU that was partially funded by NSF.

We engineer probiotics to eliminate methane from livestock. We’re a pre-seed stage company spinning out of North Carolina State University and based in the Raleigh-Durham area. We’re looking to raise $2M to get us through animal trial proof-of-concept.

At Impulse Wellness (IW), our mission is to build engaging and immersive tools that help the functionally impaired take a more active role in their recovery process. With our cutting edge technology, we will help those suffering from movement-related disorders gain an increase in long term mobility and an enhanced quality of life. We offer high-quality diagnostic and training tools that will be used to optimize therapy, speed up recovery, and fine-tune motor skills.

incredible eats’ innovated mass manufacturable technology for edible cutlery to replace millions of single use plastics. Our edible cutlery are made with vegan, non-gmo grains and can stay firm for 30 minutes in hot foods. They come in both sweet and savory flavors and are carbon and plastic negative certified. Did you eat your SPOON, SPORK and STRAWS today?

Innatrix has built a platform to generate eco-friendly biological products to control untreatable crop pests and pathogens, to help farmers to increase yields at least 10% with ROI>3. Innatrix core team has collectively over 100 years’ experience on ag product development and commercialization, and partners with several research and commercial partners. We have received U.S. patents to protect our protein evolution technology and RNAi technology, and confirmed the efficacy of 2 product leads in the lab and field conditions. We have raised over $1.5 million non-dilutive and capital funds.

We are striving to build breast implants, personalized lumpectomy molds, and repair other soft tissue defects using a person’s own tissue without the need for major reconstructive surgery. We have developed an injectable gel that allows plastic surgeons to reliably build new tissue using a patient’s own liposuctioned fat. This process, called fat grafting, is one of the fastest growing procedures in plastic and reconstruction surgery despite the fact that it is also one of the most unreliable procedures—consistently requiring repeated surgeries to achieve the desired result. Our product can revolutionize this growing industry by solving the underlying issues of stability, shape, and vasculature supply that currently limit its more widespread use.

The first ever custom-fit wearable that tracks biomechanics and helps predict and avoid injury.

Intake Health is the first company to build a wearable for your toilet to passively measure health and wellness. Our mission is to extend healthspans globally by making it easy to understand and improve your lifestyle choices, backed by a passively collected personalized data stream.

Integrated Precision Biosystems is a company designed to Democratize the scientific field of Metabolomics. Metabolomics is a field of science started in 1997 by two of the founders, Sandy Stewart and John Ryals. After 25 years of development the Founders have optimized a method that will identify and quantitate over 5000 biological molecules in a single sample. This technology is very important in understanding biomarkers, mode of action of drugs and other compounds and understanding the Phenotype. It is the final technology required for multi omics studies.

Ivy Clinicians is the simplest way for physicians, PAs, and nurse practitioners to find jobs they love. Ivy is a two-sided marketplace matching verified clinicians with medical practices, starting with the emergency medicine specialty. Ivy is the first to connect every emergency department (ED) in the US with the practice managing the emergency physicians, PAs, and nurse practitioners at that ED. With this proprietary data, as well as a large amount of publicly available information, Ivy enables verified emergency clinicians to search, filter, and connect with the right job opportunities. Simply, Ivy is the Zillow of the emergency medicine job market.

Jabin Beverage Company is a CPG startup centered around using fresh, functional ingredients to power athletes and adventurers challenging the status quo. Our flagship product is a family twist on an ancient Persian beverage recipe. We are tackling a $23B sports drink market with the goal of creating a portfolio of products that not only increase performance but are also rich in culture and history. Our competitive advantage is our level of freedom and flexibility which allows us to listen to the consumer and rapidly innovate to meet and surpass expectations. We will be the first product in the market to introduce the benefits of apple cider vinegar to athletes.

Jericho Sciences is developing novel antiviral therapeutics targeting a key viral motif shared across current and emerging viruses – called zinc finger domains. This strictly conserved motif consists of a specific sequence of amino acids that coordinate a zinc atom. Such motifs are required for critical viral functions and have been validated as desirable therapeutic targets, being strictly conserved and less prone to mutational resistance than other viral targets. Virus mutations lead to continuing drug, antibody and vaccine resistance. RNA viruses mutate. Jericho’s lead candidate has been supported by $4M nondilutive grant funding for reducing persistent sources of virus in HIV-1 infection, which is a high priority unmet need for the National Institutes of Health.

JourneyTrack.io has pioneered a customer-first, enterprise-grade SaaS experience management platform that enables organizations to understand, track, visualize and prioritize their end-to-end customer experience. This cloud-based collaboration suite allows enterprises to create, govern and democratize personas and journeys – creating a shared vision across all teams, and to benchmark improvements over time, with the goal of delivering ideal customer experiences – globally.

We are a rideshare community of women drivers and riders providing a safe, stress-free, alternative rideshare experience.

We’re enabling merchants to expand their e-commerce stack using clicks instead of code. Current platforms are not set up to lend the level of flexibility required to expand an e-commerce stack and reach customers on more mediums.

Online Mental health services for underserved communities.

Lindy Biosciences is addressing formulation challenges in the rapidly growing biotherapeutics market. Our core technology, MicroglassificationTM, produces spherical, dense, stable particles of a therapeutic protein, ideal for solid injectable formulations such as high-concentration suspensions. Over half of all antibody therapeutics are given intravenously, in part because the high dose required cannot be formulated as a solution in a volume small enough for subcutaneous injection. Lindy Biosciences has developed high-dose suspensions of protein that are suitable for subcutaneous injection, which can decrease administration costs, increase patient comfort and compliance, and enable new high-dose molecules to reach the market.

Voicelessness, or aphonia, is a debilitating condition that frequently follows life-saving airway interventions that occur during the most critical of illnesses. Current communication modalities designed to overcome voicelessness are ineffective and leave individuals isolated. LiRA has developed novel machine learning algorithms trained to recognize the specific facial movements associated with speech. The lip-reading software translates video-data into audio, thereby restoring communication for aphonic individuals. LiRA partners with patients and healthcare systems to develop next-generation voice restoration via an AI-based lip-reading software designed to empower voiceless individuals and advance their quality of medical care.

LoadHive is a dispatch automation and load management platform currently offered to carriers with 15 or more drivers. We help trucking companies to increase their revenue by eliminating the need for their dispatchers to find loads manually and respond to check calls.

Made Trade is a technology-enabled dropship retailer that curates beautifully designed, ethical and sustainable goods for the rapidly growing conscious consumer market.

Loot Loop is built as Infrastructure as a Service (IaaS) of De-Fi to service on-chain transactions and an Aggregator to enable value-added services.

LUMINELLE® is a FemTech startup dedicated to using visualization (endoscopy) to solve the issues of diagnosing and treating disease at the earliest point of care (PoC). Our immediate focus is detecting Uterine and Urological diseases during a simple office visit, specifically endometrial, bladder cancer; coupled with enabling the simplification of office procedures. We are committed to advancing the diagnosis and treatment of Uterine Cancer to the highest standard of care, with an elegant and simple solution – the LUMINELLE Bx (Biopsy) RotoSheath. Our business model of a reusable endoscope and disposable RotoSheaths allows us to quickly innovate to meet the needs of various skill levels and procedural types. Our system is FDA-cleared for diagnostic and operative Hysteroscopy and Cystoscopy.

MAA uses its patented NanoContTM platform technology to develop novel medicines with meaningful clinical benefits from currently marketed medicines. Products by MAA require small clinical trials and don’t need safety, efficacy, and toxicity studies to get the product approval through 505(b)(2) regulatory pathways by the FDA. The company has a state-of-the-art non-GMP product development and manufacturing facility in the Research Triangle Park in North Carolina.

MabSwitch Inc (Mabswitch), Los Angeles, CA, is a biotechnology company that uses a proprietary universal allosteric-linker and switch module for antibodies (UNASMA-TM) technology platform to engineer control switches to regulate the activity and improve the efficacy of next-generation antibody-based immunotherapies such as Switchable Affinity T-cell engagers (SaefTE-TM) and Switchable Affinity CAR (SaefCAR-TM) T-cell therapies. A recent awardee of a QuickFire Challenge sponsored by Johnson and Johnson and winner of a MBC Biolabs Golden Ticket supported by Abbvie, Mabswitch is currently focused on demonstrating in-vivo proof-of-concept for it’s SaefTE and SaefCAR T-Cell platforms in hematological and solid cancers with a critical unmet need.

Made Trade is a technology-enabled dropship retailer that curates beautifully designed, ethical and sustainable goods for the rapidly growing conscious consumer market.

Mentorforce is a game-changing corporate learning resource that leverages an exclusive network of senior executive mentors to provide pragmatic, on-demand guidance to corporate team members in order to improve business outcomes and career trajectories. Mentorforce fulfills this promise through the offering of a 3-tiered “turnkey” mentoring program that is scalable and affordable for companies of all sizes. The program consists of 1. on-demand video masterclasses developed and delivered by experienced executives 2. Group mentoring sessions for designated cohorts in a client organization 3. Private mentoring for individuals with the greatest desire or need.

Mersur.io offers AI-Based Supply Chain Analytics and Risk Management applications for top global food companies and government agencies who seek to manage efficient, resilient, responsible food supply chains.

MGeneRx is developing an artificial intelligence platform developed by rare disease experts, physicians and engineers that can instantly identify a child’s risk for congenital birth defects using biometric analysis. Our first application is a cost-efficient, non-invasive software for the early identification of newborn genetic dysmorphologies. The application uses a simple phone interface that enables early detection of pediatric genetic disorders using biometric data points on a patients face. To date, the software has been tested in over 6,000 cases worldwide and has an accuracy of 88% in screening genetic dysmorphologies in 128 different syndromes in children within all pediatric ages.

mign is orthopaedics, digitally tailored. mign is the world’s first digital end:end process for creating personalized spine & sports medicine bracing at scale. Using a novel combination of an in-clinic body scan, corrective anatomical modeling and 3D printing, mign reduces precious clinical service time by up to 75%, delivering a bespoke design in days versus weeks.

We make life better for moms and their babies with revolutionary products that replicate natural nursing. Our patented “breast pump that works like a baby” uses both positive and negative pressure to extract milk, replicating the action and effect of the baby’s tongue. Our “bottle that works like a mom” employs our patented compression shut-off technology, allowing the baby to regulate the flow of milk just as in nursing. The company holds 8 issued and 2 pending US patents, in addition to 8 international counterparts. Our inventor-cofounder is the former president of Medela Inc., the country’s leading breast pump company.

We are a restaurant staff management app that focuses on optimizing restaurant operations and employees onboarding.

Multi3D is delivering a new approach to next-generation electronics that is poised to transform how devices are manufactured. The company provides advanced electronic materials coupled with additive manufacturing and injection molding technologies that can be applied to everything from RF antenna and flexible circuitry to sensors and wearable devices removing the barriers of traditional approaches and ushering in a new era of flexible and multi-dimensional additive manufacturing.

MuukTest makes it effortless for growing engineering teams to ensure software quality–getting them to 95% end-to-end coverage within 3 months. All without the usual overhead. At a fraction of the cost.

MyMatR has developed the next generation of public smart waste container that automatically sorts waste at the source of disposal. We capture an image of every discarded item and sort the material into trash or recycling containers. The value for the customer is eliminating recycling contamination, reducing operations cost and increasing landfill diversion. Electronic waste stream monitoring provides data that has value for waste management operations and waste policy decisions.

Myodenovo is developing next generation cultivated meats with whole-cut thickness and realistic texture, courtesy of biomechanics. Our technologies are readily adaptable to future biomedical tissue-engineering applications.

NALA is an award winning, women led, cleantech company developing new membranes for water treatment and management. Our disruptive membrane technology will dramatically reduce the cost and complexity of desalination and high-end water treatment. NALA’s new chlorine tolerant reverse osmosis (RO) membranes will be unique in the ~$5B membrane market that is dominated today by a membrane with known limitations regarding durability and fouling that lead to high operating costs and poor reliability. NALA’s membranes are based on patent pending materials invented by our founders. NALA was funded by an NSF SBIR phase I grant to develop the proof of concept for using our new materials as reverse osmosis membranes.

Nanochon is commercializing Chondrograft(TM), an implantable device for treating arthritic cartilage damage and loss in the knee. Using 3D printing and a nanopolymer composite, the device mechanically supports areas of damaged cartilage while activating cartilage regeneration over time. The device may offer a new clinical standard for patients, ensuring fast, reliable recovery and true longevity. At the same time, Chondrograft(TM) addresses critical unmet pain points for surgeons: it is off the shelf, a one-step surgery, and fully arthroscopic. Nanochon has had excellent traction over the years, funded by competitive grants and an SBIR, and recently raised a $2.7M oversubscribed seed round.

Nanode Battery Technologies is revolutionizing the anodes for rechargeable lithium-ion batteries. The world needs safer batteries with higher capacity and lower cost. At Nanode, we are developing a next-generation tin alloy foil anode. Our anode has ~5x volumetric energy density and is ~40% lower in cost than the graphite incumbent.

Neighborhood National is a member-based high-end golf simulator sharing community on a mission to make golf more accessible, affordable, and inclusive. We’re a market place, meets world class golf simulation, meets community building platform creating the most convenient, affordable, and fun golf membership available anywhere. Our Members get unlimited golf, minutes from home, for $50 per month. Our “Club Pros” (hosts) get a high end golf simulator that pays for itself. While our stakeholders get to help solve golf’s biggest challenges, building the world’s largest private golf club, and in the process create the only intelligence platform able to integrate demographic, behavior/biometric, and outcome performance data.

Nova Thin Film Pharmaceuticals (NTFP) uses its patented Depofilm technology to develop and produce dissolvable polymeric films for rapid onset, higher bioavailability drug products via the oromucosal route of administration.

NuPulse is a clinical stage medtech company developing a minimally invasive heart support device to treat patients from hospital to home, helping them walk to their mailbox.

Nyssa creates multi patented innovations and professionally led content to support recovery of puberty to menopause.

Ultra-fast and efficient smart vision with privacy at the source. Oculi® is a fabless company with an experienced team of semiconductor and vision experts, a spin-out of Johns Hopkins University, where the founder developed the underlying technology. Oculi enables vision solutions with the efficiency of human vision and the speed of machines. The OCULI SPU is the only single chip Software-Defined Vision Sensor that delivers Real-Time Vision Intelligence (VI) with Privacy at Source; and our our partners can deliver a natural & immersive user experience under any lighting conditions, indoors and outdoors, with up to 30X reduction in power consumption and latency with a lower bill of materials.

Olfax Medical is a start-up product development and commercialization company located in Asheville, NC that specializes in nasally administered therapeutics. Our mission is to help patients avoid the harmful and addictive side effects of systemic pharmaceuticals by revolutionizing nasal drug delivery. The world of nasal drug delivery has been plagued by inefficient technology that has been essentially unchanged for the past 40 years. Pharmaceutical companies are forced to use the same metered dose nasal spray pumps for expensive, potentially life-saving drugs as they do for simple, over the counter treatments. These methods are outdated and limit potential benefits of nasal medications.

We work with companies who want to improve employee engagement or corporate social responsibility. We do this by enabling employees to give to over 1.7 million non profits using payroll deduction donations.

Oncotect is a Raleigh-based biotechnology startup committed to pioneering early screening of cancer risks in dogs using their urine. The company’s patent-pending in-vitro scientific test combines its proprietary technology and C. elegans’ highly effective olfactory receptors to detect cancerous volatile metabolites. Oncotect is the only urine-based non-invasive, convenient, affordable, and accessible multi-cancer screening test available to dogs

OpiAID is technology designed for clinics treating patients with substance use disorder. Our algorithms convert data used by clinicians into interpreted behavioral and biometric insights and presents this data smoothly within the workflow of the clinic. The purpose of OpiAID’s technology is to support clinical decision making at the point of care by providing timely and actionable data leading to improved clinical outcomes, reduced cost to payers and increased revenue for clinics.

Groundbreaking gene therapy built by and for patients with rare inherited retinal diseases (IRD): Backed by Foundation Fighting Blindness’s venture arm, the Retinal Degeneration Fund, Opus Genetics combines unparalleled insight and commitment toward patient need with wholly owned programs in numerous rare retinal diseases to create important new AAV-based retinal gene therapies for patients.

OROX BioScience is a San Diego startup biotechnology company dedicated to discovery of novel drugs. Available data indicates that our therapeutic target strategy is promising in oncological, inflammatory, and fibrotic diseases. In oncology, the underlying mechanism of action involves tumor microenvironment modification, enhancing macrophage phagocytic activity, alleviation of cytokine storm, and protection against mitochondrial damage and ER stress. Furthermore, animal studies have demonstrated that senescence is affected as a result of inhibiting our targets. Mitochondrial damage, ER stress, and cellular senescence have been shown to be involved in diseases of aging such as cancer and fibrosis.

Founded in 2019, Outsyde, Inc. seeks to sustain and restore earth’s biodiversity in a time of rapid biophysical, institutional, and cultural change. Outsyde accomplishes this with a model focused on land ownership creating asset backed digital assets. Currently, Outsyde oversees over US$45 million in land assets across the country. Outsyde strategically acquires and manages lands utilizing creative structures with comparatively high-impact, landscape scale conservation opportunities and co-benefits using a public and private partnership approach. Outsyde is creating interactive opportunities for buyers to get involved in offsetting their emissions as an effort to build more sustainably conscious brands.

Participant makes affordable assistive products, starting with a wheelchair for kids with Cerebral Palsy that fills a gap in available products. We’re serving the world’s largest minority group, people with disabilities, who are increasingly served by government health systems and a large and rapidly growing market. As the first medical device B-Corp, we are a market-based answer to WHO’s call for affordable solutions for their entire Priority Assistive Products List. Our products are clinically excellent and meet the needs of lower income countries with durability, pricing and transportability that fits local lifestyles. The leading NGO buyers are on our customer list and our founders have over 100 years of experience in the industry. 

Peoplelogic is the leader in automatic employee engagement and retention – no surveys needed. Our patented technology optimizes your organization’s health with actionable and timely insights right from everyday tools that transform the employee experience, retain your best people and, most importantly, de-risk revenue growth.

Permits.com makes it easy for contractors and licensed trade professionals to get construction-related permits, manage inspections, and access permit insights to aid in pre-project planning.

Phase, Inc, is an NIH-funded 3D printing company focused on creating next-generation microfluidics that can open new doors of bioinnovation and drug discovery.

Phinite is an Ag Robotics company that produces fertilizer from animal manure. We want to turn animal farms into the renewable fertilizer mines of the future. We do this using robotic mining operations located on farms coupled with a centralized fertilizer sales channel provided by Phinite. The Company earns revenue from dry systems sales and ongoing, recurring revenue from fertilizer sales.

Developer of cell therapies for cancer and world leader in the area of gamma/delta-T cells, an important component of the immune system.

PLAIO is a powerful visual planning tool for the pharmaceutical industry that utilizes the latest in prediction and artificial intelligence technology to help planners and supply managers optimize their manufacturing processes. Our innovative software solutions provide a direct value to the pharmaceutical industry by simplifying the planning process. Many pharmaceutical companies still rely on using Excel for this complex process, which leads to a lot of manual work and other issues. 9 out of 10 pharma companies are using excel, but with PLAIO, it’s a game changer, it’s user-friendly, with advanced forecasting tools and complete visibility into the manufacturing plan, it reduces the risk of miscommunication and errors.

Plakous Therapeutics is a human biologics company that has developed a patented, birth tissue derived, acellular platform biotherapeutic for the prevention of the rare pediatric disease, Necrotizing Enterocolitis (NEC). NEC afflicts roughly 6% of the 50,000 babies born annually in the U.S weighing less than 3lbs. and carries a 30% mortality rate. Further, NEC consumes $4.50B in overall healthcare costs. Our Founder and Management team have prior successful start-up experience. We have been awarded a $1.72M NIH grant and have received rare pediatric disease and orphan drug designations from the FDA.

Pluritem Health enables Primary Care clinics to reduce the time their staff spends tracking medical records for new patients and referrals and allows their providers to spend more time with patients by getting exactly what they need from the records.

Polaris Quantum Biotech (PolarisQB) has built the first-ever drug discovery platform on a Quantum Computer. PolarisQB technology finds small molecular drug leads rapidly, and cost-effectively, from a large chemical space using Quantum Annelaers, and providing greater numbers and of a more competitive nature of the drug leads. The leads are identified from billions of diverse virtual molecules, specific to the target protein, pocket, and property profile. We use automation for speed and accuracy, as well as to increase the scale up of the technology, such that in 2022 we worked on 15 projects, 7 with customers/collaborators.

PolyPV is developing a flexible and highly durable innovative solar power technology for the military and outdoor recreation applications.

Praetego’s novel small molecules are potent inhibitors of a known driver of serious diabetic complications and the chronic diseases of aging, including Alzheimer’s disease. The culprit is the accumulation of Advanced Glycation End-products (AGEs), a result of aberrant glucose metabolism. Because AGE pathology is fueled by glucose, it affects everyone. AGE pathology accelerates with age. Praetego’s novel candidates (the Amadorins) inhibit the formative step in AGE production, thus limiting harmful downstream consequences. The Amadorins have extensive proof of concept data in animal models of neurodegenerative diseases associated with aging.  In preclinical safety testing, the lead asset is demonstrating the ideal qualities of a chronic use oral drug.

PFI has built the first IoT platform for the fermentation industry. Our solution enables precision production, delivers lower OpEx, and virtually eliminates waste. Our solution has the potential to save over 2.3 billion gallons of water and 500 million pounds of ingredient waste every year. PFI’s proprietary platform is being used globally in multi-B$$ industries that have struggled with variability, labor-intensive processes, and avoidable waste.

ProAxion is connecting the nation’s manufacturing machines with IIoT and leveraging our cloud based predictive maintenance analytics to improve machine availability. The market problems of unanticipated line stoppage are painful with over $50B a year in lost production from plant and line stoppages. The ProAxion IIoT solution leverages vibration analysis and temperature monitoring to flag early-stage machine issues and provide diagnostics tools with recommendations to address them. Our cloud platform enables distributed stakeholders to understand priorities regardless of their geographic location, coordinating plant and corporate resources, and effectively leveraging third party service providers.

Prohuman Technologies is a medical device startup focusing on recovery wearables that provide cryo, thermo, and compression therapies. With our patent-pending technology the user can customize optimal recovery through a combination of heating (up to 120 F), cooling (down to 45 F), and compression. The device can also be outfitted with biometric sensors to create a closed-loop feedback system, monitoring and compliance aid, not to mention seamless integration with medical records. The core technology used in our electromedical wearable is referred to as a thermoelectric cooler (or peltier module) which when supplied with electrical current creates a hot and cold disparity between the two metallic alloys contained within.

Proximal is an education technology company developing VR and browser-based immersive learning experiences. Our team is three veterans of the AAA video game industry and a tenured professor, and we take a game design approach to learner engagement. Our approach to developing educational experiences is based on the experiential learning model, one of the most highly validated educational models. We envision a future in which every learner can gain the benefits of experiential learning. Our groundbreaking technology will enable experiential learning where it was previously not possible, and allow educators across subject areas to dramatically expand the range of immersive experiences that a learner can have.

QATCH Technologies is a life-science instrumentation company and a Duke University spin-out. QATCH aims to change how drug formulations are developed. QATCH’s nanovisQ technology can identify formulations that can be manufactured and injected using very small sample volumes and rapidly. Currently, QATCH has 5 full-time employees, an exclusive license to the IP for the core-technology and has filed IP on this specific application. QATCH has been funded through SBIR grants from NSF, NIH, and NIST for R&D.

Rarebird is on a mission to make coffee deliver superior experiences. We’re starting with crafted coffees that support your mental health and cognitive health. Our state-of-the art blends include the most premium ingredients to help you rise and outshine: – Naturally occurring compounds – Backed by clinical studies and FDA GRAS affirmed Our flagship product, Coffee Px, is the only true caffeine alternative available in the US today Every time we consume caffeine, enzymes in our liver convert it into an active metabolite called paraxanthine (or Px for short). Just like caffeine, Px wakes you up and increases alertness, but without many of caffeine’s negative side effects. Px is also metabolized faster than caffeine, so less remains in your body when you’re ready to go to bed.

Redbud Labs offers the worlds simplest, smallest sample prep automation platform. Our solution uses patented microfluidic technology to enable a device that is 1/8th the size and 1/10th the cost of traditional automation solutions, without sacrificing quality. With an initial focus on molecular sample prep for PCR and sequencing, our platform has applications in immunoassays, biomarker detection, and cell-based assays. We are offering early access to select users now, with commercial phase scheduled for late 2023.

A bi-lingual DIY Tax Filing app using AI/ML. We are focusing on under-served Hispanic/Latino communities. We make tax filing as easy as Uno-Dos-Tres. Its like a depositing a check using a smartphone. We are launching in 9 states which do not have state income tax and supporting single filers and married filing jointly.

Reselute, Inc. was founded in 2021 with a technology platform based on research from the Gall research lab at Duke University. Reselute’s company mission is to provide solutions for treatment of orthopedic infections to accelerate treatment and improve patient care using innovative technologies based on years of academic research. Despite the pressing clinical need, there is a large gap in solutions for treatment of orthopedic infections in the US market. Reselute’s core competency is translation of innovative biomedical technologies into commercial medical devices. This is based on the team’s demonstrated successful track record in spinning out academic based research technologies to startup medical device companies, ultimately bringing products to market that have a significant positive impact on clinical outcomes.

Salem Cyber represents business model innovation for cybersecurity operations. We build software that helps enterprise cybersecurity teams detect more threats.

Seabird Apps is the creator of Onespot, the only platform that allows anyone to create a mobile app for their community or organization in 15 minutes, with no code, entirely from their phone. It’s like Squarespace for community-specific mobile apps. You can try it out here: www.1spot.app Our mission is to fundamentally shift the general understanding that people have about what it takes to make a mobile app. The cross-platform and no-code trends are moving app-building in a powerful new direction already, and we are leapfrogging the current timeline by multiple years with our 10x improvements across the board. We want to make it dramatically easier for organizations and communities of all shapes and sizes to create mobile apps for whatever their goals are — whether they are businesses, non-profits, students, or anyone else.

ServeScape delivers homeowners & contractors a marketplace of local, plant growers, landscape designers, and industry professionals through a highly connected, cost efficient, customer-oriented supply chain.

Shipal is a web based platform that allows e-commerce small businesses and entrepreneurs access to the best shipping rates from the top couriers of their choice.

SiNON Nano Sciences patented Carbon NanoDots (CNDs) are a drug delivery system with a novel release mechanism that allows for targeted treatment for brain tumors and other neurological diseases.

SiteBridge Research is a community-focused integrated research organization, building a national network of community practices to deliver world-class industry sponsored clinical research on-time and on-budget, accelerating time to market and product adoption in communities that are historically the most vulnerable and the hardest to reach, including those of color and other medically marginalized groups. The SiteBridge network extends reach further into these communities to empower a broader set of patients with some of the highest unmet needs to take part in clinical research to improve health outcomes. SiteBridge also helps with FDA diversity planning and building effective community engagement strategies.

Social Cascade is an intelligent health literacy solution enabling pediatricians to build an active social media feed filled with critical information authored by trusted organizations supporting parents and caregivers across social determinants of health. Under the hood, our innovative platform ingests and analyzes engagement data providing unprecedented data on public health messaging strategy and impact. Such data is also used to intelligently recommend content maximizing effectiveness and providing caregivers with relevant information to drive progress on building medical trust and reducing health disparities.

Sparta has developed a first-of-its-kind technology platform, Galene, to repair damaged cartilage. Our first device is Ormi, which is to treat chondral (cartilage) and osteochondral (bone-cartilage) defects in the knee. It received Breakthrough Device Designation from the FDA. Over time Galene will be used in devices to treat other joints in which osteoarthritis is common.

Splendo Health is a Dutch-American Digital Health /AI startup from Duke University. Splendo Health’s vision for health equity is to democratize Cardiorespiratory Function (CRF) assessments to the masses using mobile apps and wearable technology. Cardiorespiratory Function (CRF) is the ability of the lungs, heart, and muscle to exchange, distribute, and consume oxygen during physical strain. And the most under-utilized vital sign when assessing the health and wellbeing of patients requiring surgery. Also, CRF assessments are limited to a hospital visit, are costly and must be approved by a physician and insurance.

Stern Security is a cybersecurity company that has created a SaaS platform called Velocity (https://www.velocitysec.com). Velocity is the most efficient and accurate product to manage internal and third-party risk. Stern Security also has a services arm that performs virtual/fractional Chief Information Security Officer (vCISO)services in addition to elite penetration testing.

Suggestion Ox is the employee feedback platform that helps leaders learn the candid truth about what their people are thinking about, not the carefully-filtered version produced by most “employee engagement” tools. Trusted by managers and HR professionals at more than 60,000 companies, Suggestion Ox lets you collect truly candid team feedback so you can prevent small problems from becoming big problems and build a happier, healthier workplace. Using the power of anonymity and a dose of psychological safety, you’ll uncover the truth and be able take action on employee concerns before you find out in the exit interview.

We are the first company globally to introduce CQD-type image sensors which provide substantial advantage for delivering very high resolution and very low cost sensors for a multiplicity of emerging applications. We are transforming the industrial machine vision infrared imaging market, with superior resolution and lowest cost IR imaging sensors, while also positioning our patented technology platform for very large strategic markets including mobile phone facial recognition sensors and autonomous driving 2D imagers.

SwitchFrame is the first end-to-end platform that allows companies to collect, edit, test, and scale unlimited combinations of video ads using real testimonials from customers and creators. SwitchFrame also leverages the power of GPT-3 (and soon GPT-4) to assist anyone in delivering powerful spoken copy in a teleprompter-like interface, regardless of their experience.

Tactyc is the first performance forecasting and scenario planning platform for VC’s. The software enables funds to construct, manage and forecast venture portfolios in a single platform, replacing traditional spreadsheet workflows. Tactyc empowers GPs to be more data-driven in capital and reserve allocations.

Talli is a configurable, a la carte platform of software and hardware options for simple tracking and sharing of daily care and health information. We started with babies because that’s where our origin story began, and we grew our revenues by more than 400% and had more than 14,000 MAUs with our Talli Baby product last year. But we are currently expanding into senior care and chronic conditions as well. After making our platform fully configurable this pass summer, we started seeing customers buying the baby product and adapting it for care of their aging loved ones. Even before releasing our Talli Care configuration marketed for senior care, we had more than 400 customers using our platform to log for someone over the age of 65.

We are the dating app for small businesses and tax professionals. You know the Tinder of Tax. Swipe left or right just find your tax pro on our marketplace.

Ten63 Therapeutics is a VC backed preclinical therapeutics company focused initially on developing drugs to combat cancer. Ten63 was founded in 2019 as a spin-out from the lab of Dr. Bruce Donald, James B. Duke Professor of Computer Science and Biochemistry at Duke University. Over the past 15 years, the Donald Lab has pioneered the computational exploration of large chemical and conformational spaces by developing provable ensemble-based search algorithms that model continuous molecular flexibility. The research resulted in multiple successful prospective designs and the unprecedented ability to model, predict and mechanically understand on-target drug resistance.

The Diversity Movement (TDM) enables organizations to build and strengthen culture by tying real-world business outcomes to diversity, equity, and inclusion (DEI) initiatives via a scalable subscription-based employee experience platform. Our integrated approach enables organizations to build inclusive culture through the application of data-informed insight, technology, and DEI expertise. Our platform is powered by 400 original digital learning lessons, 600+ micro-learning videos delivered in a “Netflix for DEI experience,” and analytics to track and measure culture-building progress.

Townhall is a fully accessible software application that measures and boost engagement in large remote meetings in real-time by creating a sticky, video game-like experience. Townhall is fully accessible and does NOT require the use of a camera or mic to measure engagement. Rooted in 15+ years of ed tech and gamification research, Townhall leverages proven gamification techniques to boost audience engagement and productivity on any platform (Zoom, MS Teams, AR, VR, etc.). Townhall creates an energizing experience and culture, which leads to less employee turnover and higher worker productivity.

We create an interactive and educational platform for families visiting zoos, amusement parks and other outdoor venues. Our goal is to enhance the guest experience, build empathy and educate families on conservation while sending them on an adventure to discover hidden secrets, unlock quests of bravery, and explore the very best that existing outdoor venues have to offer.

Led by Dr. Eric Buckland, Translational Imaging Innovations (TII) provides purpose-driven software systems that drive ophthalmic research forward. TII powers images of the eye for breakthroughs in vision science by accelerating the process, adding efficiencies, and removing barriers which eases the overall process of acquiring, annotating, analyzing, and archiving images for research studies and preclinical or clinical trials. TII’s core mission is to unlock the latent medical information in ophthalmic images, starting with secure storage and rapid access to all mission-critical images.

Truentity Health is on a mission to revolutionize healthcare by reducing preventable medication errors and hospital readmissions through our innovative medication and care management platform. Combining cutting-edge technology and human expertise, our comprehensive and secure platform allows clinical teams to compile complete and up-to-date records of a patient’s medications, allergies, and adverse reactions before and after visits. By giving providers a holistic view of a patient’s medication history and empowering patients to access and share their records with their care team, Truentity Health helps improve patient outcomes while increasing efficiency, reducing readmission rates and costs, and boosting STAR ratings and HCAHPS scores for providers.

TSV Analytics is a content generation tool for social media managers. By incorporating NLP technology into social listening, TSV determines the trending topics in any niche conversation by following hashtag and keyword mentions. By identifying trending topics, TSV Analytics is then able to create engaging post copy and ideas specifically tailored for the audience being targeted by a brand. This allows any social media manager to immediately understand (analytically) what their audience currently cares about and then generate content for that audience in just a few minutes.

UbiquiTx focuses on leveraging machine learning and protein engineering to develop programmable protein-modulating therapies. Our peptide guide design allows us to modulate almost any target protein, allowing CRISPR-like programmability for proteins. Our computational platform uses known natural interactions to design motif, mutant and PTM-specific peptides to pathogenic proteins from sequence alone. The UbiquiTx platform enables fast access to intractable protein targets that have long evaded the industry and is generalizable and applicable to any of nature’s PTMs for programmable protein modulation. As a first application, we are designing a novel class of mRNA therapeutics that potently and selectively degrade historically undruggable targets.

Venti, a service-disabled veteran owned small business (SDVOSB), is an advanced technology firm. The Company is focused on innovation for first responder/homeland security agencies utilizing its proprietary Intelipod® system (patented). Intelipod is a networked small, expendable (consumable), configurable, scalable, and deployable set of sensor pods that detect and geo-locate a wide range of data in emergency environments and transmit actionable information to ruggedized displays. The Venti solution is ‘anytime ready’, in any environment, requiring no pre-placement or set up time, and circumvents the need for personnel to enter hazardous areas for situational assessments.

We sell Vertical Solar Power and Solar Power Applications like EV Charging Stations, Security, and Rural Internet Connection. We are able to provide up to 3,000 watts on a single pole that would take Apartments, Condos, and Townhomes OFF GRID with no solar on the roof and using only a 26″ Diameter Space On the Ground.

Viamer Biosciences is an early stage company developing advanced polymer biomaterials. Our resorbable Cyprex polymer technology is uniquely versatile and tailored for targeted and controlled drug delivery.

VitalFlo helps doctors measure, monitor, and predict their patients’ lung health. VitalFlo is the predictive medicine company for chronic respiratory diseases like asthma and COPD. We help doctors monitor and manage their patients and to keep them out of the ER and hospital. We first launched our platform into academic and governmental research settings: helping them enable them to monitor patients remotely during the height of the COVID-19 pandemic. Early in 2022, we launched our in-person clinical product to clinical customers. With our hybrid model (facilitating both in-person and virtual care), VitalFlo is at the center of longitudinal patient respiratory data and physician decision-making.

Vivaspot is a cloud-based marketing platform that automates marketing for SMB Merchants by connecting to their WiFi, Point of Sale, CRM, Digital Signage and other services and then automates email, text, social media and on-location marketing.

WH Farms Co. is a seed to shelf brand of premium CBD wellness products, infused with quality extract from African American & Tuscaroran legacy farmlands of Eastern NC. Our products solve wellness problems for customers seeking to alleviate common wellness challenge such as pain management, muscle pains, anxiety relief, insomnia or overall mood boosts while also economically enriching disadvantaged farmers. In our first 2 years, we have manufactured and sold over 80k units from our CBD product line and are pace to grow rapidly due to the development of new distribution channels.

Windlift’s is a small business headquartered in Durham, North Carolina building the next generation of wind energy technology. Our Airborne Power Generators (APG) are autonomous, tethered drones that use wing-mounted turbines to generate electricity. Power generated from winds aloft is transferred through a conductive tether for use at ground level. This technology is highly scalable and solves problems for customers in market segments ranging from defense and mobile power through utility scale offshore wind. Our small-scale prototype was commissioned to serve the mobile power market. In this market, weight and portability are prized attributes and APG technology offers 10X the energy density of comparable renewables.

Winter Innovations is a seed-stage medical device startup developing simple tools for overlooked areas in surgery to improve patient outcomes. The company is commercializing its patented and FDA-cleared product, EasyWhipTM. EasyWhipTM is the industry’s first two-part suturing needle that improves biomechanical strength, speed, and consistency for stitching in orthopedic ligament and tendon surgery.

Wisely, Inc. reduces waste from farm to table through patent-pending Smart Food Storage Container Systems.

ZealCare is a human-centric and technology enabled solution that focuses on helping individuals with multiple complex conditions take control of their health. Our approach has been tested and validated for 10+ years through various divisions of Duke Health and was spun out as an independent company in 2020. Our solution of unique components delivers a 6:1 ROI to our customers and improves quality of life and well-being of program participants. These components include integrative health coaching, cultivating a community and digital tools to extend the care team and increase access to care.

Zinnia helps distributed teams come together easily, impactfully, and always on budget. Zinnia’s proprietary software reduces offsite and client EBC planning from hundreds of hours to just a few clicks.

Built by coaches for coaches, Zoee is an all-in-one virtual office software packed with powerful automation that helps coaches and solopreneurs grow their online business.

With technology originating at Cornell University, Zymtronix has opened completely new biomanufacturing possibilities with their cell-free product development and proprietary process technologies. Their novel matrices of unique immobilization materials and composition of enzymes can provide previously inaccessible molecules and fundamentally change existing product economies. The uniqueness and efficiency of the Zymtronix systems can dramatically improve the carbon footprint and sustainability profiles of the manufactured products and provide new pathways to a better future.